Standard Treatment Radiation therapy is the standard treatment, particularly for patients under the age of 40. While total lymphoid irradiation has been associated with longer disease-free survival, there is no overall survival benefit over regional or limited irradiation.
Stage III and Stage IV
Standard Treatment The best treatment for advanced-stage disease remains controversial. Options include:
• No initial treatment, with close observation for patients who have no symptoms.
• Single-drug therapy, most often oral chlorambucil or cyclophosphamide .
• Combination chemotherapy with CVP (cyclophosphamide + vincristine + prednisone) or CHOP
